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FRIDAY, JULY
16, 2010
09:00 - 18:00
Registration (Lobby, 4th Floor, Renaissance Hotel)
SATURDAY, JULY 17, 2010
07:00 – 18:00
Registration (Lobby, 4th Floor, Renaissance Hotel)
08:00 – 08:30
Opening Ceremony (Ballroom, 4th Floor, Renaissance Hotel)
Chair: Shuiping Jiang (China), Zhongmin
Liu (China)
08:30 – 10.30
Keynote Lectures
Chair: Xuetao Cao (China), Tadamitsu Kishimoto
(China)
08:30
Alexander
Rudensky, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of generation and function of regulatory T cells
09:10
Vijay
K. Kuchroo, Harvard University, USA
Effector and helper functions of Th17 cells
09:50
Xuetao
Cao, Second Military Medical University, China
RHBDD3 suppresses Th17-mediated pathogenesis
of autoimmune diseases by controlling TLR-triggered DC maturation
10:30 – 10:50
Coffee Break, Poster Viewing
10:50 – 12:00
Plenary Session 1: Development and Molecular Control of Th17 Cells
Chairs: Chen Dong (USA),
Vijay Kuchroo (USA)
10:50
Chen
Dong, MD Anderson Cancer Center, USA
Molecular controls of Th17 cell differentiation
11:15
Gerard
Eberl, Pasteur Institute, France
Symbiotic
bacteria in the development of IL-17+ lymphoid cells
11:40
Kazuo Okamoto, Tokyo Medical and Dental University, Japan
An essential role of IkBz in Th17 development (P051)
12:05 – 14:00
Lunch, Poster Viewing
13:00 – 14:00
Poster Viewing with Moderators: Bruce Blazer (USA), Steven Miller (USA),
Yasmine Belkaid (USA), and Dale Umetsu (USA)
14:00 - 16:00
Plenary Session 2: Differentiation and Regulation of Regulatory T Cells
Chairs: Alexander Rudensky (USA), Wanjun
Chen (USA)
14:00
Ludger Klein, Ludwig-Maximilians-University, Germany
Clonal deletion versus Treg differentiation of autoreactive CD4+ thymocytes
14:25
Sankar
Ghosh, Columbia University, USA
Regulation of T regulatory cells by NF-kB
15:50
Wanjun
Chen, National Institutes of Health, USA
The
enhancer and silencer in Foxp3 gene expression
15:15
Short Talk:
Ming O. Li, Memorial Sloan-Kettering Cancer Center, USA
Foxos
cooperatively control Foxp3+ regulatory T cell differentiation (P054)
15:30
Short Tal:
Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in regulatory T cells
(P005)
15:45
Short Tal:
Hye-Sook Kwon, University of California at San Francisco, USA
The SIRT1 deacetylase negatively regulates Treg differentiation by destabilizing the FOXP3 transcription factor (P121)
16:00 – 16:20
Coffee Break, Poster Viewing
16:20 - 18:15
Plenary Session 3: Molecular Control of Th17/Treg Balance
Chairs: Tadamitsu Kishimoto (Japan), Sankar
Ghosh (USA)
16:20
Tadamitsu Kishimoto, Osaka University, Japan
IL6 and Aryl hydrocarbon receptor: Regulators of Th17/Treg balance as well as macrophages
16:45
Fan
Pan, John Hopkins University, USA
Control of Th17/Treg balance by hypoxia-inducible factor 1α
17:05
Rongfu
Wang, Baylor College of Medicine, USA
Innate immune signaling controls Treg and Th17 cell differentiation and function
17:30
Short Talk:
Guobing Chen, The Australia National University, Australia
c-Rel
is involved in IL21 gene expression and associated specific T helper cell subsets development (P008)
17:45
Short Talk:
Song Guo Zheng, University of Southern California, USA
All-trans retinoic acid restores the stability and functionality of nTregs in an inflammatory milieu (P055)
18:00
Short Talk:
Ling Lu, Nanjing Medical University, China
Role of Smad and non-Smad signals in the development of Th17 and regulatory T cells (P093)
SUNDAY,
JULY 18, 2010
08:00 –
10:30 Plenary
Session 4: IL-17 in Innate Immunity
Chairs:
Daniel Cua (USA), Kingston Mills (Ireland)
08:00
Daniel
Cua, Merck Research Laboratory, USA
The protective vs. pathogenic functions of innate IL-17-producing cells
08:25
Kingston Mills, Trinity College, Ireland
The role of IL-1 in activating Th17 cells and in inducing innate IL-17 production by gd T
cells
08:50
Stephen Miller, Northwestern University, USA
IL-17-producing gd T cells play a significant role in the pathogenesis of experimental
autoimmune encephalomyelitis
09:15
Dale Umetsu, Harvard University, USA
The
regulation of asthma by subsets of natural killer T cells
09:40
Short Talk:
Akihiko Yoshimura, Keio University School of Medicine, Japan
Role of IL-23 and IL-17-producing gdT cells in the delayed phase of brain ischemia (P012)
09:55
Short Talk:
Qing-Sheng Mi, Henry Ford Health System, USA
Loss of miRNAs in the bone marrow enhances gamma/delta T cell development but reduces Th17 gamma/delta T cells (P042)
10:10 –10:30
Coffee Break, Poster Viewing
10:30 – 12:00 Plenary Session 5: Signal Transduction of Treg/Th17 Cells in Disease
Chairs:
Anne O’Garra (UK), Jingwu Zang (China)
10:30
Anne O’Garra, MRC National Institute for Medical Research, UK
Regulation
of IL-10 production by T cells and implications for immune response to pathogens
10:55
Jingwu
Zang, GlaxoSmithKline R&D China, China
Role of IL-7 and IL-7R signaling in Th17 development in autoimmune disease
11:20
Xiaoxia
Li, Cleveland Clinic, USA
CNS-restricted ablation of IL-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
11:45
Short Talk: Erik Lubberts, Erasmus MC University, The Netherlands
Vitamin D suppresses Th17 cytokines via down regulation
of RORgammat and NFATC2 and inhibits the pathogenic behavior of primary human Th17 cells from early RA patients (P110)
12:00
Short Talk: Allan SY Lau, University of Hong Kong, China
Interleukin-17 modulation of mycobacterium-induced
cytokine (P109)
12:15 – 14:00
Lunch, Poster Viewing, BD Lunch Symposium
13:10 - 13:40
BD Lunch Symposium: Xiao-Wei Xu, BD Biosciences, USA
Tools for the study of regulatory T cells: Isolation, Function and Plasticity
14:00
– 15:55
Plenary Session 6: Induction and Heterogenicity of Tregs
Chairs: Shimon Sakaguchi (Japan), Roland Liblau (France)
14:00 Shimon
Sakaguchi, Kyoto University, Japan
Construction of regulatory T cells without Foxp3
14:25 David Hafler, Yale University, USA
CD127 identifies a population of induced human CD4+CD25hi regulatory cells
14:50
Ciriaco Piccirillo, McGill University, Canada
The translatome of Foxp3+ regulatory T cells
15:15
Hans-Dieter Volk, Charite, Humboldt University,
Germany
Human regulatory T cells – the impact of heterogenicity on enrichment and expansion
15: 40
Short Talk: Joanne E. Konkel,
National Institutes of Health, USA
Insights into the role of TGFbeta in Treg generation within the thymus;
TGFbeta is important for Foxp3 induction in thymocytes (P031)
15: 55 – 16: 15 Coffee
Break, Poster Viewing
16:15 – 18:00
Plenary Session 7: Mechanism of Immune Suppression
Chairs: Ethan Shevach (USA), Larry Turka
(USA)
16:15
Ethan Shevach, National Institutes of Health, USA
Mechanisms of T regulatory cell-mediated suppression in vivo
16:40
Bin Li, University of Pennsylvania, USA
Structural insights into the regulatory function of discrete acetylated residues of the FOXP3 coiled coil subdomain in oligomerization-dependent
immune modulation
17:05
Laurence A. Turka, Harvard University, USA
Control of T cell responses by the tumor suppressor gene Pten
17:30
Short Talk: Zuojia Chen, Institute Pasteur of Shanghai, China
Identification of STUB1 as an ubiquitin E3 ligase of FOXP3 (P105)
17:45
Short Talk: Joachim Schultze, University of Bonn, Germany
Foxp3-mediated suppression of SATB1 expression in Treg cells is required for suppressive function and inhibition of effector
differentiation (P111)
MONDAY, JULY 19, 2010
08:00 - 10:00
Plenary Session 8: Homeostasis and Migration of Th17, Th22 and Tregs
Chairs: Antonio Lanzavecchia (Switzerland), Fiona Powrie (UK)
08:00
Antonio
Lanzavecchia, Institute for Research in Biomedicine, Switzerland
T lymphocyte differentiation, migration and immune regulation
08:25
Yasmine Belkaid, National Institutes of Health, USA
Endogenous mucosal adjuvants
08:50
Fiona
Powrie, University of Oxford, UK
Intestinal homeostasis: a balancing act between effector and regulatory T cell responses
09:15
Short Talk:
Yingzi Cong, University of Alabama at Birmingham, USA
Treg-IgA axis is dominant in maintenance of host immune homeostasis to microbiota (P016)
09:30
Short Talk:
Deyu Fang, Northwestern University, USA
The type III histone deacetylase Sirt1 and its activators in immune regulation and autoimmunity (P034)
09:45 – 10:05 Coffee
Break, Poster Viewing
10:05 – 12:10
Plenary Session
9: Regulatory T Cells in Autoimmunity and Tolerance
Chairs: Herman Waldmann (UK), Tyler Curiel
(USA)
10:05
Herman
Waldmann, University of Oxford, UK
Explaining Infectious Tolerance
10:30
Petra Reinke, Charité University Medicine Berlin, Germany
Regulatory T cells in transplantation – bad and good guys
10:55
Tyler Curiel, University of Texas Health Science Center, USA
B7-H1 mediates sexually dimorphic Treg function: Consequences for autoimmunity and tumor immunity
11:20
Matthias von Herrath, La Jolla Institute for Allergy and Immunology, USA
Combination therapies involving islet-antigen induced Tregs in type 1diabetes
11:45 – 14:30 Lunch,
Poster Viewing, BioLegend Lunch Symposium
12:45 – 14:20 BioLegend
Lunch Symposium: Journal Editorial Policies and Process
Chairs: Shuiping Jiang (China), Jingwu
Zang (China)
12:45
Laurie Dempsey, Senior Editor, Nature Immunology
13:05
Peter Lee, Editor-in-Chief, Immunity
13:25
Larry Turka, Editor-in-Chief, Journal of Clinical Investigation
13:45
Dangsheng Li, Deputy Editor-in-Chief, Cell Research
13: 55
Q&A
14:30 – 16:10
Plenary Oral Session 1: Tregs/Th17 Cells: Basic Sciences
Chairs: Ludger Klein (Germany) and Gerard
Eberl (France)
14:30
Takashi Maruyama, National Institutes of Health, USA
The role of Smad4 in the generation of Foxp3+ regulatory T cells and Th17 cells (P018)
14:40
Chenxia He, Institut Pasteur, France
The circadian rhythm related gene Arntl2 in Idd6 genetic locus protects against autoimmune type 1 diabetes (P003)
14:50
Beinan Wang, University of Minnesota, USA
Induction
of TGF-b1 and TGF-b1-dependent predominant Th17 differentiation by Group A Streptococcal infection (P083)
15:00
Luis Graca, University of Lisbon, Portugal
Plasticity of invariant natural killer T cells in response to TGF-b leads to the generation of distinct functional
subsets expressing Foxp3, IL-9 and IL-17 (P078)
15:10
Gang Pei, Tongji University, China
miR-326 and β-arrestin1 co-regulate Th-17 cell differentiation and function
15:30
Yan Wu, Harvard University, USA
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells suppresses anti-tumor immunity (P131)
15:40
Sascha Rutz, Genetech, USA
The Notch/delta-like4 axis regulates IL-10 production and anti-inflammatory activity of Th1 cells
(P073)
15:50
Julia Fang Gao, University of Toronto, Canada
Regulation of dendritic cells by double negative
regulatory T cells (P049)
16:00
Ana
Izcue, Max Planck Institute of Immunobiology, Germany
CTLA-4 controls peripheral Foxp3 induction (P123)
16:10 – 16:30
Coffee Break, Poster Reviewing
16:30 – 18:00
Plenary Oral Session 2: Tregs/Th17 Cells in Disease and Application
Chairs: David Hafler (USA), Matthias von
Herrath (USA)
16:30
Guang-Xian Zhang, Thomas Jefferson University, USA
3G11-CD25+CD4+ cells are a highly potent subpopulation of regulatory T cells (P030)
16:40
Jun Wu, Third Military Medical University, China
Unexpected “regulatory” role of effectors: activated CD4+Foxp3- T cells facilitate melanoma
metastasis via Qa-1-dependent suppression of NK cell cytotoxicity (P007)
16:50
Wenwei Tu, University of Hong Kong, China
Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-g- and
T-bet-dependent pathway (P011)
17:00
Bruce
Hall, University of New South Wales, Australia
IL-5
promotes induction of antigen specific CD4+CD25+Tregs that suppress autoimmune mediated demyelination
(P107)
17:10
Elmar Jaeckel, University of Hannover, Germany
Small numbers of antigen-specific regulatory T cells prevent diabetes by long-term persistence and infectious tolerance without
compromising general immunocompetence (P112)
17:20
Daniel Lowther, Imperial College London, UK
Characterisation of a spontaneous humanized murine model for multiple sclerosis (P076)
17:30
Ashish Marwaha, University of British Columbia, Canada
Children with type 1 diabetes have an increase in a Foxp3+ T cells subset that secretes IL-17 (P028)
17:40
Yingzi Ge, German Cancer
Research Center, Germany
Tumor-induced emigration of antigen-specific Treg enables the bone marrow to foster spontaneous anti-tumor T-cell responses
in breast cancer (P013)
17:50
Hans J.P.M. Koenen, Radboud University, The Netherlands
Severe plaque psoriasis is associated with an enhanced capacity of regulatory T cells to acquire a Th17-related phenotype
and lose Foxp3 (P124)
18:00 Nabila Seddiki, The University of New South Wales, Australia
Measuring antigen-specific CD39+OX40+CD25+ regulatory and CD39-OX40+CD25+
effector CD4+ T cell in viral infections (HIV, CMV) and in autoimmunity (coeliac disease)
19:00 PM –
Gala Party
TUESDAY,
JULY 20, 2010
08:00
- 10:10
Plenary Session 10: Tregs, IL-17 and IL-22 in Mucosal and Regional Inflammation
Chairs: Diane Mathis (USA),
Rachel Caspi (USA)
08:00
Diane Mathis, Harvard University, USA
Tissular regulatory T cells
08:25
Rachel Caspi, National Institutes of Health, USA
Immune privilege, T regulatory cells and autoimmunity
08:50
Wenjun Ouyang, Genentech Inc, USA
IL-22 in mucosal immunity
09:15
Jay K. Kolls, Louisiana State University, USA
Th17 Cytokines: roles in mucosal immunity and chronic inflammation
09:40
Short Talk: Georgina Xanthou, Biomedical Research Foundation of the Academy of Athens, Greece
Activin-A controls allergen-driven Th2 responses and associated allergic asthma (P114)
09:55
Short Talk:
Guangxun Meng, Institute Pasteur of Shanghai, China
Interleukine-17 dominant inflammation in experimental uveitis from mice with Nlrp3 mutation (P026)
10: 10 – 10:30 Coffee
Break, Poster Viewing
10:30 – 12:30 Plenary
Session 11: Preclinical and Clinical Application of Tregs/Th17 in Human Disease
Chairs: Yong-Jun Liu (USA), Weiping Zou (USA)
10:30
Bruce Blazar, University of Minnesota, USA
Preclinical
and clinical applications of regulatory T cells to control graft-versus-host disease (GVHD)
10:55
Yong-Jun Liu, MD Anderson Cancer Center, USA
Blocking Treg by Anti-Ox40 mAb to enhance anti-tumor immunity
11:20
Weiping Zou, University of Michigan, USA
Th17
cells in human diseases
11:45
Short Talk: Bo Huang, Huazhong University of Science & Technology, China
In vivo depletion of Treg cells by low-dose cyclophosphamide: potential treatment of HPV-infected genital wart in patients
and the underlying molecular mechanism (P002)
12:00
Short Talk: Naruyasu Kakita, Osaka University, Japan
Distinctive roles of IL-10-producing type 1 regulatory T cells (Tr1) in the pathogenesis of hepatitis C virus-infected hepatocellular
carcinoma (P133)
12: 15
End of the Conference
From 14:00
Visit to the World Expo 2010 China
